金井班
Anzai N, Jutabha, P, Kanai Y, Endou H. Integrated physiology and proximal tubular organic anion transport. Curr Opin Nephrol Hyperten. 14: 472-479, 2005.
Miyazaki H, Anzai N, Ekaratonawong S, Sakata T, Shin HJ, Jutabha P, Hirata T, Xin H, Nonotuchi H, Tomita K, *Kanai Y, Endou H. Modulation of renal apical organic anion transporter 4 function by two PDZ domain-containing proteins. J. Am. Soc Nephol. 16: 3498-3506, 2005.
Shigeta Y, *Kanai Y, Chairoungdua A, Ahmed N, Sakamoto S, Matsuo H, Kim DK, Fujimura M, Anzai N, Mizoguchi K, Ueda T, Akakura K, Ichikawa T, Ito H, Endou H. A novel missense mutation of SLC7A9 frequent in Japanese cystinuria cases affecting the C-terminus of the transporter. Kidney Int. 69: 1198-1206, 2006.
Noshiro R, Anzai N, Sakata T, Miyazaki H, Terada T, Shin HJ, He X, Miura D, Inui K, *Kanai Y, Endou H. The PDZ domain protein PDZK1 interacts with human peptide transporter PEPT2 and enhances its transport activity. Kidney Int. 70: 275-82, 2006.
Shin HJ, Anzai N, Enomoto A, He X, Kim do K, Endou H, Kanai Y. Novel liver-specific organic anion transporter OAT7 that operates the exchange of sulfate conjugates for short chain fatty acid butyrate. Hepatology. 1046-55, 2007.
Kaira K, Oriuchi N, Otani Y, Shimizu K, Tanaka S, Imai H, Yanagitani N, Sunaga N, Hisada T, Ishizuka T, Dobashi K, Kanai Y, Endou H, Nakajima T, Endo K, Mori M. Fluorine-18-alpha-methyltyrosine positron emission tomography for diagnosis and staging of lung cancer: a clinicopathologic study. Clin Cancer Res. 13: 6369-78, 2007.
Matsuo H, Chiba T, Nagamori S, Nakayama A, Domoto H, Phetdee K, Wiriyasermkul P, Kikuchi Y, Oda T, Nishiyama J, Nakamura T, Morimoto Y, Kamakura K, Sakurai Y, Nonoyama S, Kanai Y, Shinomiya N. Mutations in glucose transporter 9 gene SLC2A9 cause renal hypouricemia. Am J Hum Genet. 83: 744-51, 2008.
Sakamoto S, Chairoungdua A, Nagamori S, Wiriyasermkul P, Promchan K, Tanaka H, Kimura T, Ueda T, Fujimura M, Shigeta Y, Naya Y, Akakura K, Ito H, Endou H, Ichikawa T, *Kanai Y. A novel role of the C-terminus of b0,+AT in the ER-Golgi trafficking of the rBAT-b0,+AT heterodimeric amino acid transporter. Biochem J. 417: 441-8, 2009.
Shiraya K, Hirata T, Hatano R, Nagamori S, Wiriyasermkul P, Jutabha P, Matsubara M, Muto S, Tanaka H, Asano S, Anzai N, Endou H, Yamada A, Sakurai H, *Kanai Y. A novel transporter of SLC22 family specifically transports prostaglandins and co-localizes with 15-hydroxyprostaglandin dehydrogenase in renal proximal tubules. J Biol Chem. 285: 22141-51, 2010.
森班
Shimizu S, Yoshida T, Wakamori M, Ishii M, Okada T, Takahashi M, Seto M, Sakurada K, Kiuchi Y, Mori Y. Ca2+/calmodulin dependent myosin light chain kinase is essential for activation of TRPC5 channels expressed in HEK cells. J. Physiol. 570: 219-235, 2006.
Yoshida T, Inoue R, Morii T, Takahashi N, Yamamoto S, Hara Y, Tominaga M, Shimizu S, Sato Y, * Mori Y. Nitric oxide activates TRP channels by cysteine S-nitrosylation. Nature Chem. Biol. 2: 596-607, 2006.
Baba Y, Hayashi K, Fujii Y, Mizushima A, Watarai H, Wakamori M, Numaga T, Mori Y, Iino M, Hikida M, *Kurosaki T. Coupling of STIM1 to store-operated Ca2+ entry through its constitutive and inducible movement in the endoplasmic reticulum. Proc. Natl. Acad. Sci. USA. 103: 16704-16709, 2006.
Kiyonaka S, Wakamori M, Miki T, Uriu Y, Nonaka M, Bito H, Beedle AM, Mori E, Hara Y, De Waard M, Kanagawa M, Itakura M, Takahashi M, Campbell KP, *Mori Y. RIM1 confers sustained activity and neurotransmitter vesicle anchoring to presynaptic Ca2+ channels. Nature Neurosci. 10: 691-701, 2007.
Fujita A, Cheng J, Hirakawa M, Furukawa K, Kusunoki S, *Fujimoto T. Gangliosides GM1 and GM3 in the living cell membrane form clusters susceptible to cholesterol depletion and chilling. Mol. Biol. Cell. 18: 2112-2212, 2007.
Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, Negoro T, Hiroi T, Kiuchi Y, Okada T, Kaneko S, Lange I, Fleig A, Penner R, Nishi M, Takeshima H, *Mori Y. TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration. Nature Med. 14: 738-747, 2008.
Kiyonaka S, Kato K, Nishida M, Mio K, Numaga T, Sawaguchi Y, Yoshida T, Wakamori M, Mori E, Numata T, Ishii M, Takemoto H, Ojida A, Watanabe K, Uemura A, Kurose H, Morii T, Kobayashi T, Sato Y, Sato C, Hamachi I, *Mori Y. Selective and direct inhibition of TRPC3 channels underlies biological activities of a pyrazole compound. Proc. Natl. Acad. Sci. USA. 106: 5740-5745, 2009.
Fujita A, Cheng J, Tauchi-Sato K, Takenawa T, *Fujimoto T. A distinct pool of phosphatidylinositol 4,5-bisphosphate in caveolae revealed by a nanoscale labeling technique. Proc. Natl. Acad. Sci. USA. 106: 9256-9261, 2009.
Sun H-S, Jackson MF, Martin LJ, Jansen K, Teves L, Cui H, Kiyonaka S, Mori Y, Jones M, Forder JP, Golde TE, Orser BA, MacDonald JF, *Tymianski M. Suppression of hippocampal TRPM7 protein prevents delayed neuronal death in brain ischemia. Nature Neurosci. 12: 1300-1307, 2009.
Miyagi K, Kiyonaka S, Yamada K, Miki T, Mori E, Kato K, Numata T, Sawaguchi Y, Numaga T, Kimura T, Kanai Y, Kawano M, Wakamori M, Nomura H, Koni I, Yamagishi M, *Mori Y. A pathogenic C-terminus-truncated Polycistin-2 mutant enhances receptor-activated Ca2+ entry via association with TRPC3 and TRPC7. J. Biol. Chem. 284: 34400-34412, 2009.
Koike C, Obara T, Uriu Y, Numata T, Sanuki R, Miyata K, Koyasu T, Ueno S, Funabiki K, Tani A, Ueda H, Kondo M, Mori Y, Tachibana M, *Furukawa T. TRPM1 is a component of the retinal ON bipolar cell transduction channel in the mGluR6 cascade. Proc. Natl. Acad. Sci. USA. 107: 332-337, 2010.
Numaga T, Nishida M, Kiyonaka S, Kato K, Katano K, Mori E, Kurosaki T, Inoue R, Hikida T, Putney Jr JW, *Mori Y. Ca2+ influx and protein scaffolding via TRPC3 sustain PKCβ and ERK activation in B cells. J. Cell Sci. 123: 927-938, 2010.
Yasuda T, Shibasaki T, Minami K, Takahashi H, Mizoguchi A, Uriu Y, Numata T, Mori Y, Miyazaki JI, Miki T, *Seino S. Rim2α determines docking and priming states in insulin granule exocytosis. Cell Metab. 12: 117-129, 2010.
古川班
Bai CX, Kurokawa J, Tamagawa M, Nakaya H, *Furukawa T. Non-transcriptional regulation of cardiac repolarization currents by testosterone. Circulation. 112: 1701-1710, 2005.
Furukawa T, Bai CX, Kaihara A, Ozaki E, Kawano T, Nakaya Y, Awais M, Sato M, Umezawa Y, Kurokawa J. Ginsenoside Re, a main phytosterol of Panax ginseng, activates cardiac potassium channels via a non-genomic pathway of sex hormones. Mol. Pharmacol. 70: 1916-1924, 2006.
Furukawa T, Kurokawa J. Potassium channel remodeling in cardiac hypertrophy. J. Mol. Cell. Cardiol. 41: 753-761, 2006．
Furukawa T, Kurokawa J. Regulation of cardiac ion channels via non-genomic action of sex steroid hormones: Implication for gender-difference in cardiac arrhythmias. Pharmacol. Therapeut. 115: 106-115, 2007.
Nakamura H, Kurokawa J, Bai CX, Asada K, Xu J, Oren RV, Zhu ZI, Clancy CE, Isobe M, *Furukawa T. Progesterone regulates cardiac repolarization through a nongenomic pathway: An in vitro patch-clamp and computational modeling study. Circulation. 116: 2913-2922, 2007.
Kurokawa J, Tamagawa M, Harada N, Honda S, Bai CX, Nakaya H, Furukawa T. Acute effects of estrogen on the guinea pig and human IKr channels and drug-induced prolongation of cardiac repolarization. J. Physiol. (Lond.) 586: 2961-2973, 2008.
Asada K, Kurokawa J, *Furukawa T. Redox- and calmodulin-dependent S-nitrosylation of the KCNQ1 channel. J. Biol. Chem. 284: 6014-6020, 2009.
Kaihara A, Sunami A, Kurokawa J, *Furukawa T. A genetically encoded bioluminescent indicator for the sodium channel activity in living cells. J. Am. Chem. Soc. 131: 4188-4189, 2009.
Yang PC, Kurokawa J, Furukawa T, Clancy CE. Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: A Simulation Study. PLoS Comput. Biol. 6: e1000658, 2010.
畑班
Hirabayashi S, Mori H, Kansaku A, *Kurihara H, Sakai T, Shimizu, F, Kawachi H, *Hata Y. MAGI-1 is a component of the glomerular slit diaphragm that is tightly associated with nephrin. Lab Invest. 85: 1528-1543, 2005. * double correspondence
Kansaku A, Hirabayashi S, Mori H, Fujiwara N, Kawata A, Ikeda M, Rokukawa C, Kurihara H, *Hata Y. Ligand-of-Numb protein X is an endocytic scaffold for junctional adhesion molecule 4. Oncogene. 25: 5071-5084, 2006.
Iida J, Ishizaki H, Okamoto-Tanaka M, Kawata A, Sumita K, Ohgake S, Sato Y, Yorifuji H, Nukina N, Ohashi K, Mizuno K, Tsutsumi T, Mizoguchi A, Miyoshi J, Takai Y, *Hata Y. S-SCAMalpha is a scaffold to mediate NMDA receptor-dependent RhoA activation in dendrites. Mol Cell Biol. 27: 4388-4405, 2007.
Ikeda M, Hirabayashi S, Fujiwara N, Mori H, Kawata A, Iida J, Bao Y, Sato Y, Iida T, Sugimura H, *Hata Y. Ras-association domain family protein 6 induces apoptosis via both caspase-dependent and caspase-independent pathways. Exp Cell Res. 313: 1484-1495, 2007.
Sumita K, Sato Y, Iida J, Kawata A, Hamano M, Hirabayashi S, Ohno K, Peles E, *Hata Y. S-SCAM/MAGI-2 is associated with cell adhesion molecules at inhibitory synapses at rat hippocampal neurons. J Neurochem. 100: 154-166, 2007.
Ikeda M, Kawata A, Nishikawa M, Tateishi Y, Yamaguchi M, Nakagawa K, Hirabayashi S, Bao Y, Hidaka S, Hirata Y, *Hata Y. Hippo pathway-dependent and -independent roles of RASSF6. Science Signal. 2: ra59, 2009.
木下班
Tsuchiya Y, *Kinoshita K, Nakamura H. Analysis of homo- oligomer interfaces of proteins from the complementarity of molecular surface, electrostatic potential and hydrophobicity. Protein Eng. Des. Sel. 19: 421-429, 2006.
Kinoshita K, Murakami Y, Nakamura H. eF-seek: prediction of the functional sites of protein by searching for similar electrostatic potential and molecular surface shape. Nuc. Acids Res. 35: w398-w402, 2007.
Kanamori E, Murakami Y, Tsuchiya Y, Standley D, Nakamura H, *Kinoshita K. Docking of protein molecular surfaces with evolutionary trace analysis. Proteins. 69: 832-8, 2007.
Hosaka Y, Iwata M, Kamiya N, Yamada M, Kinoshita K, Fukunishi Y, Tsujimae K, Hibino H, Aizawa Y, Inanobe A, Nakamura H, *Kurachi Y. Mutational analysis of block and facilitation of HERG current by a class III anti-arrhythmic agent, nifekalant. Channels. 1: 198-208, 2007.
Obayashi T, Hayashi S, Shibaoka M, Saeki M, Ohta H, *Kinoshita K. COXPRESdb: a database of coexpressed gene networks in mammals. Nucleic Acids Res.36: D77-82, 2008.
Higurashi M, Ishida T, *Kinoshita K. Identification of transient hub proteins and genthe possible structural basis for their multiple interactions. Protein Sci. 17: 72-78, 2008.
Ishida T, Kinoshita K. Prediction of disordered protein regions based on meta-approach. Bioinformatics. 24: 1433-1348, 2008.
Obayashi T, Hayashi S, Saeki M, Ohta H, *Kinoshita K. ATTED-II provides coexpressed gene networks for Arabidopsis. Nucleic Acids Res. 37: D987-991, 2009.
Obayashi T, *Kinoshita K. Rank of correlation coefficient as a comparable measure for biological significance of gene coexpression. DNA research. 5: 249-260, 2009.
Kinoshita K, Obayashi T. Multi-dimensional correlations for gene coexpression and application to the large-scale data of Arabidopsis. Bioinformatics. 20: 2677-2684, 2009.
竹島班
Yoshida M, Minamisawa S, Komazaki S, Shimura M, Kume H, Zhang M, Matsumura K, Nishi M, Saito M, Ishikawa Y, Yanagisawa T, *Takeshima H. Impaired Ca2+ store functions in skeletal and cardiac muscle cells from sarcalumenin-deficient mice. J. Biol. Chem. 280: 3500-3506, 2005.
Togho A, Eiraku M, Miyazaki T, Miura E, Kawaguchi S, Nishi M, Watanabe M, Hirano T, Kengaku M, *Takeshima H. Impaired cerebellar functions in mutant mice lacking DNER. Mol. Cell. Neurosci. 31: 326-333, 2006.
Moriguchi S, Nishi M, Komazaki S, Sakagami H, Miyazaki T, Masumiya H, Saito S, Watanabe M, Kondo H, Yawo H, Fukunaga K, *Takeshima H. Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins. Proc. Natl. Acad. Sci. USA. 103: 10811-10816, 2006.
Weisleder N, Brotto M, Komazaki S, Pan Z, Zhao X, Nosek T, Parness J, Takeshima H, *Ma J. Muscle aging is associated with compromised Ca2+ spark signaling and segregated intracellular Ca2+ release. J. Cell Biol. 174: 639-645, 2006.
Kakizawa S, Kishimoto Y, Hashimoto K, Miyazaki T, Furutani K, Shimizu H, Fukaya M, Nishi M, Sakagami H, Ikeda A, Kondo H, Kano M, Watanabe M, Iino M, *Takeshima H. Junctophilin-mediated channel crosstalk essential for cerebellar synaptic plasticity. EMBO J. 26: 1924-1933, 2007.
Zhang M, Yamazaki T, Yazawa M, Treves S, Nishi M, Murai M, Shibata E, Zorzato F, *Takeshima H. Calumin, a novel Ca2+-binding transmembrane protein on the endoplasmic reticulum. Cell Calcium. 42: 83-90, 2007.
Yazawa M, Ferrante C, Feng J, Mio K, Ogura T, Zhang M, Lin P-H, Pan Z, Komazaki S, Kato K, Nishi M, Zhao X, Weisleder N, Sato C, Ma J, *Takeshima H. TRIC channels are essential for Ca2+ handling in intracellular stores. Nature. 448: 78-82, 2007.
Cai C, Masumiya H, Weisleder N, Matsuda N, Nishi M, Hwang M, Ko J-K, Lin P, Thornton A, Zhao X, Pan Z, Komazaki S, Brotto M, *Takeshima H, *Ma J. (*co-corresponding authors) MG53 nucleates assembly of cell membrane repair machinery. Nature Cell Biol. 11: 56-64, 2009.
Yamazaki T, Yamazaki D, Takeshima H.* New molecular components supporting ryanodine receptor-mediated Ca2+ release: roles of junctophilin and TRIC channel in embryonic cardiomyocyes. Pharmacol. Ther. 121: 265-272, 2009.
Takeshima H. Junctophilin. Encyclopedia of movement disorders. (Elsevier Limitted, Oxford, UK. 2009)
Weisleder N, Takeshima H, Ma J. Mitsugumin 53 (MG53) facilitates vesicle trafficking in striated muscle to contribute to cell membrane repair. Commun. Integr. Biol. 3: 225-226, 2009.
中西班
Uezu A, Horiuchi A, Kanda K, Kikuchi N, Umeda K, Tsujita K, Suetsugu S, Araki N, Yamamoto H, Takenawa H, *Nakanishi H. SGIP1α is an endocytic protein that directly interacts with phospholipids and Eps15. J. Biol. Chem. 282: 26481-26489, 2007.
Makino K, Umeda K, Uezu A, Hiragami Y, Sakamoto T, Ihn H, *Nakanishi H. Identification and characterization of the novel centrosomal protein centlein. Biochem. Biophys. Res. Commun. 366: 958-962, 2008.
Sakamoto T, Uezu A, Kawauchi S, Kuramoto T, Makino K, Umeda K, Araki N, Baba H, *Nakanishi H. Mass spectrometric analysis of microtubule-cosedimented proteins from rat brain. Genes Cells. 13: 295-312, 2008.
日比野班
Hibino H, *Kurachi Y. Molecular and physiological bases of the K+ circulation in the mammalian inner ear. Physiology (Bethesda). 21: 336-345, 2006.
Shibata T, Hibino H, Doi K, Suzuki T, Hisa Y, *Kurachi Y. Gastric type H+,K+-ATPase in the cochlear lateral wall is critically involved in formation of the endocochlear potential. Am J Physiol Cell Physiol. 291: C1038-1048, 2006.
Su S, Ohno Y, Lossin C, Hibino H, Inanobe A, *Kurachi Y. Inhibition of astroglial inwardly rectifying Kir4.1 channels by a tricyclic antidepressant, nortriptyline. J Pharmacol Exp Ther. 320: 573-580, 2006.
Ohno Y, Hibino H, Lossin C, Inanobe A, *Kurachi Y. Inhibition of astroglial Kir4.1 channels by selective serotonin reuptake inhibitors. Brain Res. 1178: 44-51, 2007.
Hibino H, *Kurachi Y. Distinct detergent-resistant membrane microdomains (lipid rafts) respectively harvest K+ and water transport systems in brain astroglia. Eur J Neurosci. 26: 2539-2555, 2008.
Nin F§, Hibino H§, Doi K, Suzuki T, Hisa Y, *Kurachi Y. The endocochlear potential depends on two K+ diffusion potentials and an electrical barrier in the stria vascularis of the inner ear. Proc Natl Acad Sci USA. 105: 1751-1756, 2008. §equal contribution.
Lachheb S, Cluzeaud F, Bens M, Genete M, Hibino H, Lourdel S, Kurachi Y, Vandewalle A, Teulon J, *Paulais M. Kir4.1/Kir5.1 channel forms the major K+ channel in the basolateral membrane of mouse renal collecting duct principal cells. Am J Physiol; Renal Physiol. 294: F1398-F1407, 2008.
Furutani K, Ohno Y, Inanobe A, Hibino H, *Kurachi Y. Mutational and in silico analyses for antidepressant block of astroglial inward-rectifier Kir4.1 channel. Mol Pharmacol. 75: 1287-95, 2009.
Hibino H, Inanobe A, Furutani K, Murakami S, Findlay I, *Kurachi Y. Inwardly rectifying potassium channels: their structure, function, and physiological roles. Physiol Rev. 90: 291-366, 2010.
Hibino H, Nin F, Tsuzuki C, *Kurachi Y. How is the highly positive endocochlear potential formed? The specific architecture of the stria vascularis and the roles of the ion-transport apparatus. Pflugers Arch. 459: 521-533, 2010.
末次班
Tsujita K, Suetsugu S, Sasaki N, Furutani M, Oikawa T, *Takenawa T. Coordination between the actin cytoskeleton and membrane deformation by a novel membrane tubulation domain of PCH proteins is involved in endocytosis. J Cell Biol. 172: 269-79, 2006.
Suetsugu S, Kurisu S, Oikawa T, Yamazaki D, Oda A, *Takenawa T. Optimization of WAVE2 complex-induced actin polymerization by membrane-bound IRSp53, PIP(3), and Rac. J Cell Biol. 173: 571-85, 2006.
Suetsugu S, Murayama K, Sakamoto A, Hanawa-Suetsugu K, Seto A, Oikawa T, Mishima C, Shirouzu M, *Takenawa T, *Yokoyama S. The RAC binding domain/IRSp53-MIM homology domain of IRSp53 induces RAC-dependent membrane deformation. J Biol Chem. 281: 35347-58, 2006.
Takenawa T, Suetsugu S. The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nature Reviews Mol Cell Biol. 8; 37-48, 2006.
Shimada A, #Niwa H, #Tsujita K, #Suetsugu S, Nitta K, Hanawa-Suetsugu K, Akasaka R, Nishino Y, Toyama M, Chen, Liu Z-J, Wang B-C, Yamamoto M, Terada T, Miyazawa A, Shirouzu M, Tanaka A, Sugano S, Nagayama K, *Takenawa T, *Yokoyama S. Gently-curved EFC-domain dimers are joined end to end into a filament for membrane invagination in endocytosis. Cell. 129: 761-772, 2007. (# equal contribution)
Takano K, Toyooka K, *Suetsugu S. EFC/F-BAR proteins and the N-WASP-WIP complex induce membrane-curvature dependent actin polymerization. EMBO J. 27: 2817-28, 2008.
Shimada A, Takano K, Shirouzu M, Hanawa-Suetsugu K, Terada T, Toyooka K, Umehara T, Yamamoto M, Yokoyama S, ＊Suetsugu S. Mapping of the basic amino-acid residues responsible for tubulation and cellular protrusion by the EFC/F-BAR domain of pacsin2/Syndapin II. FEBS Lett. 584: 1111-1118, 2008.
Takenawa T, Suetsugu S. The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nat Rev Mol Cell Biol. 8, 37-48, 2007.
Suetsugu S, Toyooka K, Senju Y. Subcellular membrane curvature mediated by the BAR domain superfamily proteins. Semin Cell Dev Biol, 21: 340-349, 2010.
楠見班
Suzuki K, Ritchie K, Kajikawa E, Fujiwara T, *Kusumi A. Rapid hop diffusion of a G-protein-coupled receptor in the plasma membrane as revealed by single-molecule techniques. Biophys. J. 88: 3659-3680, 2005
Morone N, Fujiwara T, Murase K, Kasai RS, Ike H, Yuasa S, Usukura J, Kusumi A. Three-dimensional reconstruction of the membrane skeleton at the plasma membrane interface by electron tomography. J. Cell Biol. 174: 851-62, 2006.
Suzuki KGN, Fujiwara TK, Sanematsu F, Iino R, Edidin M, Kusumi A. GPI-anchored receptor clusters transiently recruit Lyn and Gαfor temporary cluster immobilization and Lyn activation: single-molecule tracking study 1. J. Cell Biol. 177: 717-730, 2007.
Subczynski WK, Wisniewska A, Hyde JS, Kusumi A. Three-dimensional dynamic structure of the liquid-ordered domain in lipid membranes as examined by pulse-EPR oxygen probing. Biophys J. 92: 1573-1584, 2007.
Umemura YM, Vrljic M, Nishimura SY, Fujiwara TK, Suzuki KG, *Kusumi A. Both MHC class II and its GPI-anchored form undergo hop diffusion as observed by single-molecule tracking. Biophys J. 95: 435-450, 2008.
Morone N, Nakada C, Umemura Y, Usukura J, Kusumi A. Three-dimensional molecular architecture of the plasma-membrane-associated cytoskeleton as reconstructed by freeze-etch electron tomography. Methods in Cell Biology 88, Introduction to Electron Microscopy for Biologists. T. Allen Ed. Chapter. 12: 207-236, 2008.
Kusumi A, Umemura Y, Morone N, Fujiwara T. Paradigm shift of the molecular dynamics concept in the cell membrane: high-speed single-molecule tracking revealed the partitioning of the cell membrane. Anomalous Transport: Foundations and Applications. R. Klages Ed. Chapter 19, Wiley Interscience. 545-574, 2008.
Kusumi A, Shirai YM, Koyama-Honda I, Suzuki KG, Fujiwara TK. Hierarchical organization of the plasma membrane: Investigations by single-molecule tracking vs. fluorescence correlation. FEBS Lett. 584: 1814-1823, 2010.
仁科班
Kitagawa D, Kajiho H, Negishi T, Ura S, Watanabe T, Wada T, Ichijo H, Katada T, *Nishina H. Release of RASSF1C from the nucleus by DAXX degradation links DNA damage and SAPK/JNK activation. EMBO J. 25: 3286-3297, 2006.
Ura S, * Nishina H, Gotoh Y, Katada T. Activation of the JNK patyway by MST1 is essential and sufficient for the induction of chromatin condensation during apoptosis. Mol. Cell. Biol. 27: 5514-5522, 2007.
Nakamura T, Imai Y, Matsumoto T, Sato S, Takeuchi K, Igarashi K, Harada Y, Azuma Y, Krust A, Yamamoto Y, Nishina H, Takeda S, Takayanagi H, Metzger D, Kanno J, Takaoka K, Martin TJ, Chambon P, Kato S. Osteoclastic estrogen receptor alpha mediates the osteoprotective estrogen action through Fas ligand signaling. Cell. 130: 811-823, 2007.
Wada T, Stepniak E, Hui L, Leibbrandt A, Katada T, Nishina H, Wagner EF, Penninger JM. Antagonistic control of cell fates by JNK and p38-MAPK signaling. Cell Death Differ. 15: 89-93, 2008.
Tanemura S, Momose H, Shimizu N, Kitagawa D, Seo J, Yamasaki T, Nakagawa K, Kajiho H, Penninger JM, Katada T, *Nishina H. Blockage by SP600125 of Fce Receptor-induced degranulation and cytokine gene expression in mast cells is mediated through inhibition of phosphatidylinositol 3-kinase signaling pathway. J. Biochem. 145: 345-354, 2009. (Cover of the issue)
Ohata S, Nawa M, Kasama T, Yamasaki T, Sawanoboria K, Hata S, Nakamura T, Asaoka Y, Watanabe T, Okamoto H, Hara T, Terai S, Sakaida I, Katada T, *Nishina H. Hematopoiesis-dependent expression of CD44 in murine hepatic progenitor cells. Biochem. Biophys. Res. Commun. 379: 817-823, 2009.
Negishi T, Nagai Y, Asaoka Y, Ohno M, Namae M, Mitani H, Sasaki T, Nobuyoshi Shimizu, Terai S, Sakaida I, Kondoh H, Katada T, Furutani-Seiki M, *Nishina H. Retinoic acid signaling positively regulates liver specification by inducing wnt2bb gene expression in medaka. Hepatology 51: 1037-1045, 2010.
Nakagawa K, Sugahara M, Yamasaki T, Kajiho H, Takahashi S, Hirayama J, Minami Y, OhtaY, Watanabe T, Hata Y, Katada T, *Nishina H. Filamin Associates with Stress Signaling Kinases MKK7 and MKK4 and Regulates JNK Activation. Biochem. J. 427: 237-245, 2010.
Seo J, Asaoka Y, Nagai Y, Hirayama J, Yamasaki T, Namae M, Ohata S, Shimizu N, Negishi T, Kitagawa D, Kondoh H Furutani-Seiki M, Penninger JM, Katada T, *Nishina H. Negative regulation of wnt11 by JNK signaling is required for convergent extension during vertebrate gastrulation. J. Cell. Biochem. in press
Wu J, Kubota J, Hirayama J, Nagai Y, Nishina S, Yokoi T, Asaoka Y, Seo J, Shimizu N, Kajiho H, Watanabe T, Azuma N, Katada T, *Nishina H. p38 Mitogen-Activated Protein Kinase Controls a Switch between Cardiomyocyte and Neuronal Commitment of Murine Embryonic Stem Cells by Activating MEF2C-dependent BMP2 Transcription Stem Cells and Development. in press
根本班
Oshima A, Kojima T, Dejima K, Hisa Y, Kasai H, *Nemoto T. Two-photon microscopic analysis of acetylcholine-induced mucus secretion in guinea pig nasal glands. Cell Calcium. 37: 349-357, 2005.
Liu TT, Kishimoto T, Hatakeyama H, Nemoto T, Takahashi N, *Kasai H. Exocytosis and endocytosis of small vesicles in PC12 cells studied with TEPIQ (two-photon extracellular polar-tracer imaging-based quantification) analysis. J. Physiol. 568: 917-29, 2005.
Kishimoto T, Kimura R, Liu TT, Nemoto T, Takahashi N, *Kasai H. Vacuolar sequential exocytosis of large dense-core vesicles in adrenal medulla. EMBO J. 25: 673-82, 2006.
Kasai H, Kishimoto T, Nemoto T, Hatakeyama H, Liu TT, Takahashi N. Two-photon excitation imaging of exocytosis and endocytosis and their spatial organizations”, Adv. Drug Deliv. Rev. 58: 850-77, 2006.
Nemoto T. Living cell functions and morphology revealed by two-photon microscopy in intact neural and secretory organs. Mol. Cell. 26: 113-120, 2008.
Tomosugi W, Matsuda T, Tani T, Kotera I, Saito K, Horikagwa K, Nemoto T, *Nagai T. An ultramarine fluorescent protein with high photostability and pH insensitivity. Nature Methods, 6: 351-353, 2009.
Takatsuru Y, Fukumoto D,Yoshitomo M, Nemoto T, Tsukada H, *Nabekura J. Neuronal circuit remodeling in the contralateral cortical hemisphere during functional recovery from cerebral infarction. J. Neurosci. 29: 10081-6, 2009.
Ohta E, Itoh T, Nemoto T, Kumagai J, Ko S. B.H., Ishibashi K, Ohno M, Uchida K, Ohta A, Sohara E, Uchida S, Sasaki S, * Rai T. Pancreas-specific aquaporin 12 null mice showed increased susceptibility to caerulein-induced acute pancreatitis. Am. J. Physiol. Cell Physiol. 297: C1368-78, 2009.
Ebisuno Y, Katagiri Y, Katakai T, Ueda Y, Nemoto T, Inada H, Nabekura J, Okada T, Kannagi R, Tanaka T, Miyasaka M, Hogg N, *Kinashi T. Rap1 controls lymphocyte adhesion cascade and interstitial migration within lymph nodes in a RAPL-dependent and -independent manner. Blood. 115: 804-14, 2010.
宮本班
Saito H, Maeda A, Ohtomo S, Hirata M, Kusano K, Kato S, Ogata E, Segawa H, *Miyamoto KI, Fukushima N. Circulating FGF-23 is regulated by 1alpha,25-dihydroxyvitamin D3 and phosphorus in vivo. J Biol Chem. 280: 2543-2549, 2005
Nashiki K, *Taketani Y, Takeichi T, Sawada N, Yamamoto H, Ichikawa M, Arai H, Miyamoto K, Takeda E. Role of membrane microdomains in PTH-mediated down-regulation of NaPi-IIa in opossum kidney cells. Kidney Int. 68: 1137-47, 2005.
Segawa H, Yamanaka S, Ito M, Kuwahata M, Shono M, Yamamoto T, *Miyamoto K. Internalization of renal type IIc Na-Pi cotransporter in response to a high-phosphate diet. Am J Physiol Renal Physiol. 288: F587-96, 2005.
Segawa H, Yamanaka S, Ohno Y, Onitsuka A, Shiozawa K, Aranami F, Furutani J, Tomoe Y, Ito M, Kuwahata M, Tatsumi S, Imura A, Nabeshima Y, *Miyamoto K. Correlation between hyperphosphatemia and type II Na/Pi cotransporter activity in klotho mice. Am J Physiol Renal Physiol. 292: F769-79, 2006.
Segawa H, Yamanaka S, Onitsuka A, Tomoe Y, Kuwahata M, Ito M, Taketani Y, *Miyamoto K. Parathyroid hormone-dependent endocytosis of renal type IIc Na-Pi cotransporter. Am J Physiol Renal Physiol. 292: F395-403, 2007.
Tatsumi S, Ishii K, Amizuka N, Li M, Kobayashi T, Kohno K, Ito M, Takeshita S, * Ikeda K. Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab. 5: 464-475, 2007.
Yamamoto T, Michigami T, Aranami F, Segawa H, Yoh K, Nakajima S, Miyamoto K, Ozono K. Hereditary hypophosphatemic rickets with hypercalciuria: a study for the phosphate transporter gene type IIc and osteoblastic function. J Bone Miner Metab. 25: 407-13, 2007.
Segawa H, Onitsuka A, Kuwahata M, Hanabusa E, Furutani J, Kaneko I, Tomoe Y, Aranami F, Matsumoto N, Ito M, Matsumoto M, Li M, Amizuka N, Miyamoto K. Type llc sodium-dependent phosphate transporter regulates calcium metabolism. J Am Soc Nephrol. 20: 104-13, 2008.
Segawa H, Onitsuka A, Furutani J, Kaneko I, Aranami F, Matsumoto N, Tomoe Y, Kuwahata M, Ito M, Matsumoto M, Li M, Amizuka N, Miyamoto K. Npt2a and Npt2c in mice play distinct and synergistic roles in inorganic phosphate metabolism and skeletal development. Am J Physiol Renal Physiol. 297: F671-8, 2009.
Ishiguro M, Yamamoto H, Masuda M, Kozai M, Takei Y, Tanaka S, Sato T, Segawa H, Taketani Y, Arai H, Miyamoto K, Takeda E. Thyroid hormones regulate phosphate homoeostasis through transcriptional control of the renal type IIa sodium-dependent. Biochem J. 427: 161-9. 2010.
Tomoe Y, Segawa H, Shiozawa K, Kaneko I, Tominaga R, Hanabusa E, Aranami H, Furutani J, Kuwahara S, Tatsumi S, Matsumoto M, Ito M, Miyamoto K. Phosphaturic action of fibroblast growth factor 23 in Npt2 null mice. Am J Physiol Renal Physiol. 298: F1341-50. 2010.
Ito M, Sakurai A, Hayashi K, Ohi A, Kangawa N, Nishiyama T, Sugino S, Uehata Y, Kamahara A, Sakata M, Tatsumi S, Kuwahata M, Taketani Y, Segawa H, Miyamoto K. An apical expression signal of the renal type IIc Na+-dependent phosphate cotransporter in renal prithelial cells. Am J Physiol Renal Physiol. 2010 Apr 21.(Epub ahead of print)
鈴木班
Hayashi H, Takada T, Suzuki H, Onuki R, Hofmann AF, *Sugiyama Y. Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep. Biochim Biophys Acta. 1738: 54-62, 2005.
Ito K, Suzuki H, Horie T, Sugiyama Y. Apical/basolateral surface expression of drug transporters and its role in vectorial drug transport. Pharm Res. 22: 1559-1577, 2005.
Mita S, Suzuki H, Akita H, Hayashi H, Onuki R, Hofmann AF, *Sugiyama Y. Vectorial transport of unconjugated and conjugated bile salts by monolayers of LLC-PK1 cells doubly transfected with human NTCP and BSEP or with rat Ntcp and Bsep. Am J Physiol Gastrointest Liver Physiol. 290: G550-G556, 2006.
Yamanashi Y, *Takada T, Suzuki H. Niemann-Pick C1-like 1 overexpression facilitates ezetimibe-sensitive cholesterol and beta-sitosterol uptake in CaCo-2 cells. J Pharmacol Exp Ther. 320: 559-564, 2007.
Okada K, *Shoda J, Kano M, Suzuki S, Ohtake N, Yamamoto M, Takahashi H, Utsunomiya H, Oda K, Sato K, Watanabe A, Ishii T, Itoh K, Yamamoto M, Yokoi T, Yoshizato K, Sugiyama Y, Suzuki H. Inchinkoto, a herbal medicine, and its ingredients dually exert Mrp2/MRP2-mediated choleresis and Nrf2-mediated antioxidative action in rat livers. Am J Physiol Gastrointest Liver Physiol. 292: G1450-G1463, 2007.
Narushima K, *Takada T, Yamanashi Y, Suzuki H. Niemann-pick C1-like 1 mediates alpha-tocopherol transport. Mol Pharmacol. 74: 42-49, 2008.
Kariya Y, *Honma M, Aoki S, Chiba A, Suzuki H. Vps33a mediates RANKL storage in secretory lysosomes in osteoblastic cells. J Bone Mineral Res. 24: 1741-1752, 2009.
Ikebuchi Y, Takada T, Ito K, Anzai N, Kanai Y, *Suzuki H. Receptor for activated C-kinase 1 regulates the cellular localization and function of ABCB4. Hepatol Res, Hepatol Res. 39: 1091-1107, 2009.
Matsuo H, Takada T, Ichida K, Nakamura T, Nakayama A, Ikebuchi Y, Ito K, Kusanagi Y, Chiba T, Tadokoro S, Takada Y, Oikawa Y, Inoue H, Suzuki K, Okada R, Nishiyama J, Domoto H, Watanabe S, Fujita M, Morimoto Y, Naito M, Nishio K, Hishida A, Wakai K, Asai Y, Niwa K, Kamakura K, Nonoyama S, Sakurai Y, Hosoya T, Kanai Y, Suzuki H, Hamajima N, Shinomiya N. Common Defects of ABCG2, a High-capacity Urate Exporter, Cause Gout: A Function-based Genetic Analysis in a Japanese Population. Science Trans Med. 1: 41-48, 2009.
Minami S, Ito K, Honma M, Ikebuchi Y, Anzai N, Kanai Y, Nishida T, Tsukita S, Sekine S, Horie T, *Suzuki H. Posttranslational regulation of Abcc2 expression by SUMOylation system. Am J Physiol Gastrointest Liver Physiol. 296: G406-413, 2009.
Aoki S, *Honma M, Kariya Y, Nakamichi Y, Ninomiya T, Takahashi N, Udagawa N, Suzuki H. Function of OPG as a traffic regulator for RANKL is crucial for controlled osteoclastogenesis. J Bone Miner Res. 2010. in press.
寺崎班
Fujiyoshi M, Ohtsuki S, Hori S, Tachikawa M, *Terasaki T. 24S-Hydroxycholesterol induces cholesterol release from choroid plexus epithelial cells in an apical- and apoE isoform-dependent manner concomitantly with the induction of ABCA1 and ABCG1 expression. J. Neurochem. 100: 968-978, 2007.
Ohtsuki S, Yamaguchi H, Asashima T, *Terasaki T. Establishing a method to isolate rat brain capillary endothelial cells by magnetic cell sorting and dominant mRNA expression of multidrug resistance-associated protein 1 and 4 in highly purified rat brain capillary endothelial cells. Pharm. Res. 24: 688-694, 2007.
Ohtsuki S, Ito S, Matsuda A, Hori S, Abe T, *Terasaki T. Brain-to-blood elimination of 24S-hydroxycholesterol from rat brain is mediated by organic anion transporting polypeptide 2 (oatp2) at the blood-brain barrier. J. Neurochem. 103: 1430-1438, 2007.
Ohtsuki S, Yamaguchi H, Katsukura Y, Asashima T, *Terasaki T. mRNA expression levels of tight junction protein genes in mouse brain capillary endothelial cells highly purified by magnetic cell sorting. J. Neurochem. 104: 147-154, 2008.
Kamiie J, Ohtsuki S, Iwase R, Ohmine K, Katsukura Y, Yanai K, Sekine Y, Uchida Y, Ito S, *Terasaki T. Quantitative atlas of membrane transporter proteins: Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria. Pharm. Res. 25: 1469-1483, 2008.
Akanuma S, Hosoya K, Ito S, Tachikawa M, * Terasaki T, Ohtsuki S. Involvement of multidrug resistance-associated protein 4 in efflux transport of prostaglandin E2 across mouse blood-brain barrier and its inhibition by intravenous administration of cephalosporins. J. Pharmacol. Exp. Ther. 99: 912-919, 2010
Ohtsuki S, *Terasaki T. Contribution of carrier-mediated transport systems to the blood-brain barrier as a supporting and protecting interface for the brain; importance for CNS drug discovery and development. Pharm. Res. 24: 1745-1758, 2007.
内田班
Uchida S, Sohara E, Rai T, Ikawa M, Okabe M, Sasaki S. Impaired urea accumulation in the inner medulla of mice lacking the urea transporter UT-A2. Mol Cell Biol. 25: 7357-7363, 2005.
Suzuki T, Rai T, Hayama A, Sohara E, Suda S, Itoh T, Sasaki S, *Uchida S. Intracellular localization of ClC chloride channels and their ability to form hetero-oligomers. J Cell Physiol. 206: 792-798, 2006.
Rai T, Sasaki S, *Uchida S. The polarized trafficking of the aquaporin-3 water channel is mediated by an N-Terminal Sorting Signal. Am J Physiol Cell Physiol. 290: C298-C304, 2006.
Sohara E, Rai T, Yang SS, Uchida K, Nitta K, Horita S, Ohno M, Harada A, Sasaki S, *Uchida S. Pathogenesis and treatment of autosomal-dominant nephrogenic diabetes insipidus caused by an aquaporin 2 mutation. Proc Natl Acad Sci U S A. 103: 14217-14222, 2006.
Chiga M, Rai T, Yang SS, Ohta A, Takizawa T, Sasaki S, *Uchida S. Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone. Kidney Int. 74: 1403-9, 2008.
Noda Y, Horikawa S, Kanda E, Yamashita M, Meng H, Eto E, Li Y, Kuwahara M, Hirai K, Pack C, Kinjo M, Okabe S, Sasaki S. Reciprocal interaction with G-actin and tropomyosin is essential for aquaporin-2 trafficking. J. Cell Biol. 182: 587-601, 2008.
Okutsu R, Rai T, Kikuchi A, Ohno M, Uchida K, Sasaki S, *Uchida S. AKAP220 colocalizes with AQP2 in the inner medullary collecting ducts.Kidney Int. 74: 1429-33, 2008.
Yang SS, Morimoto T, Rai T, Chiga M, Sohara E, Ohno M, Uchida K, Lin S-H, Moriguchi T, Shibuya H, Kondo Y, Sasaki S, *Uchida S. Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4 D561A/+ knock-in mouse model. Cell Metab. 5: 331-344, 2007.
Yui N, Okutsu R, Sohara E, Rai T, Ohta A, Noda Y, Sasaki S, *Uchida S. FAPP2 is required for aquaporin-2 apical sorting at trans-Golgi network in polarized MDCK cells. Am. J. Physiol. Cell Physiol. 297: 1389-1396, 2009.
Ohta E, Itoh T, Nemoto T, Kumagai J, Ko SB, Ishibashi K, Ohno M, Uchida K, Ohta A, Sohara E, Uchida S, Sasaki S, Rai T. Am. J. Physiol. Cell Physiol. 297: 1368-78, 2009.
Ohta A, Rai T, Yui N, Chiga M, Yang SS, Lin SH, Sohara E, Sasaki S, *Uchida S. Targeted disruption of the Wnk4 gene decreases phosphorylation of Na-Cl cotransporter, increases Na excretion and lowers blood pressure. Hum. Mol. Genet. 18: 3978-86, 2009.
■研究成果 - 公募研究による主な発表論文
神谷班
Suto F, Tsuboi M, Kamiya H, Mizuno H, Kiyama Y, Komai S, Shimizu M, Sanbo M, Yagi T, Hiromi Y, Chedotal A, Mitchel KJ, Manabe T, *Fujisawa H. Interactions between plexin-A2, plexin-A4, and semaphorin 6A control lamina-restricted projection of hippocampal mossy fibers. Neuron 53: 535-547, 2007. (Suto, Tsuboi, Kamiya; equal contribution)
Uchigashima M, Fukaya M, Watanabe M, *Kamiya H. Evidence against GABA release from glutamatergic mossy fiber terminals in the developing hippocampus. J. Neurosci. 27: 8088-8100, 2007.
小倉班
Fujita H. Ogura T. Tamagawa M. Uemura H. Sato T. Ishida A. Imamaki M. Kimura F. Miyazaki M. *Nakaya H. A key role for the subunit SUR2B in the preferential activation of vascular KATP channels by isoflurane. Br. J. Pharmacol. 149: 573-580, 2006.
広瀬班
Sultana N, Nag K, Hoshijima K, Laird DW, Kawakami A, *Hirose S. Zebrafish early cardiac connexin, Cx36.7/Ecx, regulates myofibril orientation and heart morphogenesis by establishing Nkx2.5 expression. Proc. Natl. Acad. Sci. USA. 105: 4763-4768, 2008.
Esaki M, Hoshijima K, Nakamura N, Munakata K, Tanaka M, Ookata K, Asakawa K, Kawakami K, Wang W, Weinberg ES, *Hirose S. Mechanism of development of ionocytes rich in vacuolar-type H+-ATPase in the skin of zebrafish larvae. Dev. Biol. 329: 116-129, 2009.
赤塚班
H. Inoue, H. Ohtaki, T. Nakamachi, S. Shioda *Y. Okada Anion channel blockers attenuate delayed neuronal cell death induced by transient forebrain ischemia. J. Neurosci. Res. 85, 1427-1435, 2007.
H. Inoue *Y. Okada Role of volume-sensitive chloride channel in excitotoxic neuronal injury. J. Neurosci. 27, 1445-1455, 2007.
横井班
Sano H, *Yokoi M. Striatal medium spiny neurons terminate in a distinct region in the lateral hypothalamic area and do not directly innervate orexin/hypocretin- or melanin-concentrating hormone- containing neurons. J.Neurosci. 27: 6948-6955, 2007.
Sano H, Nagai Y, Miyakawa T, Shigemoto R, *Yokoi M, Increased social interaction in mice deficient of the striatal medium spiny neuron-specific phosphodiesterase 10A2. J Neurochem. 105, 546-56, 2008.
金澤班
Ohgaki R, Fukura N, Matsushita M, Mitsui K, Kanazawa H. Cell surface levels of organellar Na+/H+ exchanger isoform 6 are regulated by interaction with RACK1 J. Biol. Chem. 283: 4417-4429, 2008.
Ohgaki R, Matsushita M, Kanazawa H, Ogihara S, Hoekstra D, van Ijzendoorn SC. The Na+/H+ exchanger NHE6 in the endosomal recycling system is involved in the development of apical bile canalicular surface domains in HepG2 cells. Mol Biol Cell. 21: 1293-1304, 2010.
児嶋班
Terawaki S, Maesaki R, *Hakoshima T. Structural Basis for NHERF Recognition by ERM Proteins. Structure, 14: 777-789, 2006.
Mishima M, Wakabayashi S, *Kojima C. Solution structure of the cytoplasmic region of Na+/H+ exchanger 1 complexed with essential cofactor calcineurin B homologous protein 1. J. Biol. Chem. 282: 2741-2751, 2007.
大塚(正)班
Jung SK, Morimoto R, Otsuka M, *Omote H. Transmembrane topology of vesicular glutamate transporter 2. Biol Pharm Bull. 29: 547-9, 2006.
Uehara S, Jung SK, Morimoto R, Arioka S, Miyaji T, Juge N, Hiasa M, Shimizu K, Ishimura A, Otsuka M, Yamamoto A, Maechler P, *Moriyama Y. Vesicular storage and secretion of L-glutamate from glucagon-like peptide 1-secreting clonal intestinal L cells. J Neurochem. 96: 550-60, 2006.
吉浦班
Sakurai A, Onishi Y, Hirano H, Seigneuret M, Obanayama K, Kim G, Liew EL, Sakaeda T, Yoshiura K, Niikawa N, Sakurai M, *Ishikawa T. Quantitative structure--activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDR1). Biochemistry. 46: 7678-7693, 2007.
Toyoda Y, Sakurai A, Mitani Y, Nakashima M, Yoshiura K, Nakagawa H, Sakai Y, Ota I, Lezhava A, Hayashizaki Y, Niikawa N, *Ishikawa T. Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type? FASEB J. 23: 2001-2013, 2009.
山崎班
Ishibashi K, *Yamazaki J, Okamura K, Teng Y, Kitamura K, Abe K. Roles of CLCA and CFTR in electrolyte re-absorption from rat saliva, J. Dent. Res. 85, 1101-1105, 2006.
Ishibashi K, Okamura K, *Yamazaki J. Involvement of apical P2Y2 receptor-regulated CFTR activity in muscarinic stimulation of Cl- reabsorption in rat submandibular gland, Am. J. Physiol.: Regul. Integr. Comp. Physiol. 294: R1729-R1736, 2008.
若林班
Ben Ammar, Y., Takeda, S., Hisamitsu, T., Mori. H., *Wakabayashi,S. Crystal structure of CHP2 complexed with NHE1-cytosolic region and an implication for pH regulation. EMBO J. 25: 2315-2325, 2006.
Nakamura T Y, Iwata Y, Arai Y, Komamura K, *Wakabayashi S. Activation of Na+/H+ exchanger 1 is sufficient to generate Ca2+ signals that induce cardiac hypertrophy and heart failure. Circ. Res. 103: 891-899, 2008.
後藤班
Mukai A, Yamamoto-Hino M, Awano W, Watanabe W, *Komada M, *Goto S. Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wingless/Wnt. EMBO J. 29: 2114-2125, 2010
Midorikawa R, Yamamoto-Hino M, Awano W, Hinohara Y, Suzuki E, Ueda R, *Goto S. Autophagy-dependent rhodopsin degradation prevents retinal degeneration in Drosophila. J. Neurosci. in press
酒井（規）班
Nobukuni M, Mochizuki H, Okada S, Kameyama N, Tanaka A, Yamamoto H, Amano T, Seki T, *Sakai N. The C-terminal region of serotonin transporter is important for its trafficking and glycosylation. J. Pharmacol. Sci. 111: 392-404, 2009
藤田班
Ohzono C, Etoh S, Matsumoto K, Nakayama I, Hirota Y, Tanaka Y, *Fujita H. “Nedd4-interactin protein 2 (NDFIP2), a short half-life lysosomal membrane protein, negatively controls down-regulation of connexin43” Biol. Pharm. Bull. 33: 951-957, 2010.
森口班
Moriguchi S, Nishi M, Komazaki S, Sakagami H, Miyazaki T, Masumiya H, Saito S, Watanabe M, Kondo H, Yawo H, Fukunaga K, * Takeshima H: Functional uncoupling between Ca2+ release and afterhyperpolarization in mutant hippocampal neurons lacking junctophilins. Proc. Natl. Acad. Sci. USA. 103: 10811-10816, 2006.
三輪班
Ueno A, Miwa Y, Miyoshi K, Horiguchi T, Inoue H, Ruspita I, Abe K, Yamashita K, Hayashi E, *Noma T. Constitutive Expression of Thrombospondin 1 in MC3T3-E1 Osteoblastic Cells Inhibits Mineralizaion. J Cell physiol. 209: 322-332, 2006
薩班
*Satsu H, Shimizu M. Food factors that regulate intestinal inflammation: evaluation of the factors using a coculture system. Animal Cell Technol. 14: 29-37, 2006.
Takaishi M, Yoshida K, Satsu H, *Shimizu M. Transepithelial transport of α-lipoic acid across human intestinal Caco-2 cell monolayers. J. Agric. Food Chem. 55: 5253-5259, 2007.
田中班
Matsugami RT, Tanemura K, Mieda M, Nakatomi R, Yamada K, Kondo T, Ogawa M, Obata K, Watanabe M, Hashikawa T, *Tanaka K. Indispensability of glutamate transporters GLAST and GLT1 to brain development. Proc. Natl. Acad. Sci. USA. 103: 12161-12166, 2006.
Harada T, Harada C, Nakamura K, Qua HMA, Okumura A, Namekata K, Saeki T, Aihara M, Yoshida H, Mitani A, *Tanaka K. The potential role of glutamate transporters in the pathogenesis of normal tension glaucoma. J Clin Invest. 117: 1763-1770, 2007.
木下（彩）班
Uemura K, Kuzuya A, Shimozono Y, Aoyagi N, Ando K, Shimohama S, *Kinoshita A. GSK3beta activity modifies the localization and function of presenilin1. J Biol Chem. 282: 15823-32, 2007.
Uemura K, Lill CM, Banks M, Asada M, Aoyagi N, Ando K, Kubota M, Kihara T, Nishimoto T, Sugimoto H, Takahashi R, Hyman BT, Shimohama S, Berezovska O, *Kinoshita A. N-cadherin-based adhesion enhances Abeta release and decreases Abeta42/40 ratio. J. Neurochem. 108: 350-60, 2009.
杉田班
Sugita M. Taste perception and coding in the periphery. Cell. Mol. Life Sci. 63: 2000-2015, 2006.
Shintani T, *Hirono C, Sugita M, Iwasa Y, Shiba Y. Suppression of carbachol-induced oscillatory Cl- secretion by forskolin in rat parotid and submandibular acinar cells. Am J Physiol. 294: G738-G747, 2008.
(平成20，21年度 公募研究)
山田班
Yamamoto T, Nishiuchi Y, Teshima T, Matsuoka H, * Yamada K. Synthesis of 2-NBDLG, a fluorescent derivative of L-glucosamine; the antipode of D-glucose tracer 2-NBDG. Tetrahedron Lett. 49: 6876-6878, 2008.
楠原班 (平成18，19年度より継続)
Hasegawa M, Kusuhara H, Adachi M, Schuetz J.D, Takeuchi K, *Sugiyama Y. Multidrug resistance-associated protein 4 is involved in the urinary excretion of hydrochlorothiazide and furosemide. J Am Soc Nephrol. 18: 37-45, 2007.
Kusuhara H, Sugiyama Y. In vitro-in vivo extrapolation of transporter-mediated clearance in the liver and kidney. Drug Metab Pharmacokinet. 24: 37-52, 2009.
Ito S, Kusuhara H, Kuroiwa Y, Wu C, Moriyama Y, Inoue K, Kondo T, Yuasa H, Nakayama H, Horita S, *Sugiyama Y. Potent and specific inhibition of mMate1-mediated efflux of type i organic cations in the liver and kidney by pyrimethamine. J Pharmacol Exp Ther. 333: 341-50, 2010.
高森班
Schenck S, Wojcik SM, Brose N, *Takamori S. A chloride conductance in VGLUT1 underlies maximal glutamate loading into synaptic vesicles. Nat Neurosci. 12: 156-162, 2009.
大塚(稔)班 (平成18，19年度より継続)
Inoue E, Mochida S, Takagi H, Higa S, Deguchi-Tawarada M, Takao-Rikitsu E, Inoue M, Yao I, Takeuchi K, Kitajima I, Setou M, *Ohtsuka T, Takai, Y. SAD: a presynaptic kinase associated with synaptic vesicles and the active zone cytomatrix that regulates neurotransmitter release. Neuron. 50: 261-275. 2006.
Yao I, Takagi H, Ageta H, Kahyo T, Sato S, Hatanaka K, Fukuda Y, Chiba T, Morone N, Yuasa S, Inokuchi K, Ohtsuka T, MacGregor G R, Tanaka K, Setou M. SCRAPPER-Dependent ubiquitination of active zone protein RIM1 regulates synaptic vesicle release. Cell. 130: 943-957, 2007.
Hida Y, *Ohtsuka T. CAST and ELKS Proteins: Structural and Functional Determinants of the Presynaptic Active Zone. J. Biochem. In press.
森島班
Morishima S, Suzuki F, Yoshiki H, Md Anisuzzaman AS, Sathi ZS, Tanaka T, Muramatsu I. Identification of the alpha1L-adrenoceptor in rat cerebral cortex and possible relationship between alpha1L- and alpha1A-adrenoceptors. Br J Pharmacol. 153: 1485-1494, 2008.
Muramatsu I, Suzuki F, Nishimune A, Anisuzzaman A, Yoshiki H, Su TH, Chang CK, Morishima S. Expression of distinct alpha(1)-adrenoceptor phenotypes in the iris of pigmented and albino rabbits. Br J Pharmacol. 158: 354-360, 2009.
王子田班 (平成18，19年度より継続)
Ojida A, Honda K, Shinmi D, Kiyonaka Y, Mori Y, *Hamachi I．Oligo-asp tag/Zn(II)-complex probe as a new pair for labeling and fluorescence imaging of proteins. J Am Chem Soc. 128: 10452-10459, 2006.
Nonaka H, Tsukiji S, Ojida A, *Hamachi I. Non-Enzymatic covalent protein labeling using a reactive tag. J Am Chem Soc. 129: 15777-15779, 2007.
月田班
Nojima H, Adachi M, Matsui T, Tsukita Sh, * Tsukita Sa. IQGAP3 regulates cell proliferation through the Ras/ERK signaling cascade. Nature Cell Biol. 10: 971-978, 2008.
Tamura A, Kitano Y, Hata M, Katsuno T, Moriwaki K, Sasaki H, Hayashi H, Suzuki Y, Noda T, Furuse M, Tsukita Sh, *Tsukita Sa. Megaintestine in claudin-15 deficient mice. Gastroenterology. 134: 523-534, 2008.
上山班
Ueyama T, Kusakabe T, Karasawa S, Kawasaki T, Shimizu A, Son J, Leto TL, Miyawaki A, *Saito N. Sequential binding of cytosolic phox proteins to phagosomes through regulated adaptor proteins: evaluation using the novel monomeric Kusabira-Green system and live imaging of phagocytosis, J Immunol. 181, 629-640, 2008.
Kawasaki T, Ueyama T, Lange I, Feske S, *Saito N. PKC-induced phosphorylation of Orai1 regulates intracellular Ca2+ level via store operated Ca2+ channel. J Biol Chem. in press.
森山班
Miyaji T, Echigo N, Hiasa M, Senoh S, Omote H, *Moriyama Y. Identification of a vesicular aspartate transporter. Proc. Natl. Acad. Sci. USA. 105, 11720-11724, 2008.
Sawada K, Echigo N, Juge N, Miyaji T, Otsuka M, Omote H, Yamamoto A, *Moriyama Y. Identification of a vesicular nucleotide transporter. Proc Natl Acad Sci USA. 105: 5683-5686, 2008.
柚﨑班
Ito-Ishida A, Miura E, Emi K, Matsuda K, Iijima T, Kondo T, Kohda K, Watanabe M, *Yuzaki M. Cbln1 regulates rapid formation and maintenance of excitatory synapses in mature cerebellar Purkinje cells in vitro and in vivo. J. Neurosci. 28, 5920-30, 2008.
Nishiyama J, Matsuda K, Kakegawa W, Yamada N, Motohashi J, Mizushima N, *Yuzaki M. Reevaluation of neurodegeneration in lurcher mice: constitutive ion fluxes cause cell death with, not by, autophagy. J. Neurosci. 30: 2177-2187, 2010.
Nishiyama J, *Yuzaki M. Excitotoxicity and autophagy: lurcher may not be a model of "autophagic cell death." Autophagy. 6: 568-570, 2010.
Matsuda K, Miura E, Miyazaki T, Kakegawa W, Emi K, Narumi S, Fukazawa Y, Ito-Ishida A, Kondo T, Shigemoto R, Watanabe M, *Yuzaki M. Cbln1 is a ligand for an orphan glutamate receptor delta2, a bidirectional synapse organizer. Science, 328: 363-8, 2010.
久保(義)班 (平成18，19年度より継続)
Mio K, Kubo Y, Ogura T, Yamamoto T, Arisaka F, *Sato C. The motor protein prestin is a bullet-shaped molecule with inner cavities. J. Biol. Chem. 283: 1137-1145, 2008.
Nagatomo K, *Kubo Y. Caffeine activates mouse TRPA1 channels but suppresses human TRPA1 channels. Proc. Natl. Acad. Sci., USA. 105: 17373-17378, 2008.
Matsushita S, Nakata H, Kubo Y, Tateyama M. Ligand-induced rearrangements of the GABAB receptor revealed by fluorescence resonance enrgy transfer. J. Biol. Chem. 285: 10291-10299, 2010.
若森班
Mashimo T, Ohmori I, Ouchida M, Ohno Y, Tsurumi T, Miki T, Wakamori M, Ishihara S, Yoshida T, Takizawa A, Kato M, Hirabayashi M, Sasa M, Mori Y, *Serikawa T. A missense mutation of the gene encoding voltage-dependent sodium channel (Nav1.1) confers susceptibility to febrile seizures in rats. J Neurosci 30: 5744-5753, 2010.
Uriu Y, Kiyonaka S, Miki T, Yagi M, Akiyama S, Mori E, Nakao A, Beedle AM, Campbell KP, Wakamori M, *Mori Y. RIMg isoforms lacking the Rab3-binding domain induce long-lasting currents but block neurotransmitter vesicle-anchoring in voltage-dependent P/Q-type Ca2+ channels. J Biol Chem. 285: 21750-21767, 2010.
丸山班 (平成18，19年度より継続)
Oshaga, A., Murata, Y., Kondo, Y., Hira, R., *Maruyama, Y. Asymmetry of Rb+ conduction emerged under bi-ionic conditions in epithelial Maxi-K+ Channels. J.Physiol.Sci. 58: 363-9, 2008.
Riichiro Hira, Naoki Honkura, Jun Noguchi, Yoshio Maruyama, George J. Augustined, Haruo Kasai, Masanori Matsuzaki Transcranial optogenetic stimulation for functional mapping of the motor cortex. J.Neuroscience Methods. 179: 258-263, 2009.
酒井班 (平成18，19年度より継続)
Morii M, Yamauchi M, Ichikawa T, Fujii T, Takahashi Y, Asano S, Takeguchi N, Sakai H. Involvement of the H3O+-Lys-164-Gln-161-Glu-345 charge transfer pathway in proton transport of gastric H+,K+-ATPase. J. Biol. Chem. 283: 16876-16884, 2008.
Fujii T, Takahashi Y, Itomi Y, Fujita K, Morii M, Tabuchi Y, Asano S, Tsukada K, Takeguchi N, *Sakai H. K+-Cl- cotransporter-3a up-regulates Na+,K+-ATPase in lipid rafts of gastric luminal parietal cells. J. Biol. Chem. 283: 6869-6877, 2008.
Fujii T, Takahashi Y, Ikari A, Morii M, Tabuchi Y, Tsukada K, Takeguchi N, *Sakai H. Functional association between K+-Cl- cotransporter-4 and H+,K+-ATPase in the apical canalicular membrane of gastric parietal cells. J. Biol. Chem. 284: 619-629, 2009.
宇治原班 (平成18，19年度より継続)
T. Ujihara*, S. Suzuki, Y. Yamauchi, R. Tero, Y. Takeda,”Local concentration of gel phase domains in supported lipid bilayers under light irradiation in binary mixture of phospholipids doped with dyes for photoinduced activation”. Langmuir. 24: 10974-10980, 2008.
R. Tero*, T. Ujihara, T. Urisu, ”Lipid Bilayer Membrane with Atomic Step Structure:Supported Bilayer on Step-and-Terrace TiO2(100) Surface”. Langmuir. 24: 11567-11576, 2008.
梅田班
Ikenouchi J, Umeda M. FRMD4A regulates epithelial polarity by connecting Arf6 activation with the PAR complex. Proc. Natl. Acad. Sci. USA. 107: 748-753, 2010.
Takeuchi K, Nakano Y, Kaneda M, Aizu M, Yamaguchi A, Kato U, Awano W, Kiyonaka S, Mori S, Yamamoto D, *Umeda M.: Changes in temperature preference and energy homeostasis in dystroglycan mutants. Science. 323, 1740-1743, 2009.
松尾班
Hozoji M, Munehira Y, Ikeda Y, Makishima M, Matsuo M, Kioka N, *Ueda K. Direct interaction of nuclear receptor Liver X Receptor-beta with ABCA1 modulates cholesterol efflux. J. Biol. Chem. 283: 30057-30063, 2008.
今泉班 (平成18，19年度より継続)
Ohno A, Ohya S, Yamamura H, *Imaizumi Y. Gender difference in BK channel expression in amygdala complex of rat brain. Biochem Biophys Res Commun. 378: 867-871, 2009.
Matsushita Y, Ohya S, Suzuki Y, Itoda H, Kimura T, Yamamura H, *Imaizumi Y. Inhibition of Kv1.3 potassium current by phosphoinositides and stromal-derived factor-1α in Jurkat T cells. Am J Physiol Cell Physiol. 296: C1079-C1085, 2009.
Ohno A, Ohya S, Yamamura H, *Imaizumi Y. Regulation of ryanodine receptor mediated Ca2+ release in vas deferens smooth muscle cells. J Pharmacol Sci. 110: 78-86, 2009.
赤羽班
Masumiya H, Asaumi Y, Nishi M, Minamisawa S, Adachi-Akahane S, Yoshida M, Kangawa K, Ito K, Kagaya Y, Yanagisawa T, Yamazaki T, Ma J, Takeshima H.: Mitsugumin 53-mediated maintenance of K+ currents in cardiac myocytes. Channels (Austin). 3: 6-11, 2009.
Akaike, T., Jin, M.H., Yokoyama, U., Izumi-Nakaseko, H., Qibin, J., Iwasaki, S., Iwamoto, M., Nishimaki, S., Sato, M., Yokota, S., Kamiya, Y., Adachi-Akahane, S., Ishikawa, Y., Minamisawa, S. Promotion of oxygenation-induced migration and contraction in the rat ductus arteriosus by t-type Ca2+ channels. J. Biol. Chem. (in press)
岩本班 (平成18，19年度より継続)
Iwamoto T, Kita S. YM-244769, a novel Na+/Ca2+ exchange inhibitor that preferentially inhibitsNCX3, efficiently protects against hypoxia/reoxygenation-induced SH-SY5Y neuronal cell damage. Mol. Pharmacol. 70: 2075-2083, 2006. .
Sakamoto K, Owada Y, Shikama Y, Wada I, Waguri S, Iwamoto T, Kimura J : Involvement of Na+/Ca2+ exchanger in migration and contraction of rat cultured tendon fibroblasts. J Physiol. 587: 5345-5359, 2009.
Iwamoto T, Kita S. Hypertension, Na+/Ca2+ exchanger, and Na+, K+-ATPase. Kidney Int. 69: 2148-2154, 2006.
下川班 (平成18，19年度より継続)
Seki T, *Shimokawa N, Iizuka H, Takagishi K, Koibuchi N. Abnormalities of vertebral formation and Hox expression in congenital kyphoscoliotic rat. Mol. Cell. Biochem. 312:193-199, 2008.
Odawara H, Iwasaki T, Horiguchi J, Rokutanda N, Hirooka K, Miyazaki W, Koibuchi Y, Shimokawa N, Iino Y, Takeyoshi I, Koibuchi N. Activation of aromatase expression by retinoic acid receptor-related orphan receptor (ROR) alpha in breast cancer cells: identification of a novel ROR response element. J Biol Chem. 284: 17711-17719, 2009.
Shimokawa N, Haglund K, Holter SM, Grabbe C, Kirkin V, Koibuchi N, Schultz C, Rozman J, Hoeller D, Qiu CH, Londono MB, Ikezawa J, Jedlicka P, Stein B, Schwarzacher WS, Wolfer PD, Ehrhardt N, Heuchel R, Nezis I, Brech A, Schmidt MH, Fuchs H, Gailus-Durner V, Klingenspor M, Bogler O, Wurst W, Deller T, Harbe de Angelis M, Dikic I. CIN85 regulates dopamine receptor endocytosis and governs behavior in mice. EMBO J. 29: 2421-2432, 2010.
清水班
Satsu H, Hiura Y, Mochizuki K, Hamada M, Shimizu M. Activation of the pregnane X receptor and induction of MDR1 by dietary phytochemicals. J. Agric. Food Chem. 56: 5366-5373, 2008.
Satsu H, Hyun JS, Shin HS, Shimizu M. Cycloheximide treatment induces the uptake of neutral and dibasic amino acids via the activation of system b0,+ in human intestinal Caco-2 cells. J. Nutr. Sci. Vitaminol. 55: 44-51, 2009.
柿澤班
Kakizawa S, Moriguchi S, Ikeda A, Iino M, Takeshima H. Functional crosstalk between cell-surface and intracellular channels mediated by junctophilins essential for neuronal functions. Cerebellum. 7: 385-391, 2008.
洪班
Ishiguro H, Steward MC, Naruse S, Ko SB, Goto H, Case RM, Kondo T, Yamamoto A.CFTR functions as a bicarbonate channel in pancreatic duct cells. J Gen Physiol. 133: 315-26, 2009.
Ko SB, Mizuno N, Yatabe Y, Yoshikawa T, Ishiguro H, Yamamoto A, Azuma S, Naruse S, Yamao K, Muallem S, Goto H. Aquaporin 1 water channel is overexpressed in the plasma membranes of pancreatic ducts in patients with autoimmune pancreatitis. J Med Invest. 56: 318-321, 2009.
Ko SB, Mizuno N, Yatabe Y, Yoshikawa T, Ishiguro H, Yamamoto A, Azuma S, Naruse S, Yamao K, Muallem S, Goto H. Corticosteroids correct aberrant CFTR localization in the duct and regenerate acinar cells in autoimmune pancreatitis. Gastroenterology. 138: 1988-96, 2010.
木下(専)班 (平成18，19年度より継続)
Ihara M, Yamasaki N, Hagiwara A, Tomimoto H, Kitano A, Tanigaki A, Hikawa E, Noda M, Takanashi M, Mori H, Hattori N, Miyakawa T, *Kinoshita M. Sept4, a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity. Neuron. 53: 519-533, 2007.
Iwaisako K, *Hatano E, Taura K, Nakajima A, Tada M, Seo S, Tamaki N, Sato F, Ikai I, Uemoto S, Kinoshita M. Loss of Sept4 exacerbates liver fibrosis through the dysregulation of hepatic stellate cells. J Hepatol. 49: 768-778, 2008.
Tooley A.J, Gilden J, Jacobelli J, Beemiller P, Trimble W.S, Kinoshita M, *Krummel M.F. Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nat Cell Biol. 11: 17-26, 2009.
Tooley AJ, Gilden J, Jacobelli J, Beemiller P, Trimble WS, Kinoshita M, Krummel MF. Amoeboid T lymphocytes require the septin cytoskeleton for cortical integrity and persistent motility. Nature Cell Biology. 11: 17-26, 2009.
Kinoshita M, Takeda S. Connecting the dots between septins and the DNA damage checkpoint. Cell. 130: 777-779, 2007.
Kinoshita M, Barral Y. The septins: structure and diverse biological functions. (In Cell structure and Dynamics Review Series; eds. K. Oegema and Y. Zheng) Curr. Opin. Cell Biol. 20: 12-18, 2008.
乾班 (平成18，19年度より継続)
Masuda S, Terada T, Yonezawa A, Tanihara Y, Kishimoto K, Katsura T, Ogawa O, *Inui K. Identification and functional characterization of a new human kidney-specific H+/organic cation antiporter, kidney-specific multidrug and toxin extrusion 2. J Am Soc Nephrol. 17: 2127-2135, 2006.
Yonezawa A, Masuda S, Katsura T, *Inui K. Identification and functional characterization of a novel human and rat riboflavin transporter, RFT1. Am J Physiol Cell Physiol. 295: C632-641, 2008.
Aoki M, Terada T, Ogasawara K, Katsura T, Hatano E, Ikai I, *Inui K. Impact of regulatory polymorphisms in organic anion transporter genes in the human liver. Pharmacogenet Genomics. 19: 647-656, 2009.
Tsuda M, Terada T, Mizuno T, Katsura T, Shimakura J, *Inui K. Targeted disruption of the multidrug and toxin extrusion 1 (mate1) gene in mice reduces renal secretion of metformin. Mol Pharmacol 75: 1280-1286, 2009.
Toyama K, Yonezawa A, Tsuda M, Masuda S, Yano I, Terada T, Osawa R, Katsura T, Hosokawa M, Fujimoto S, Inagaki N, *Inui K. Heterozygous variants of multidrug and toxin extrusions (MATE1 and MATE2-K) have little influence on the disposition of metformin in diabetic patients. Pharmacogenet Genomics, 2010.
金川班
Sato S, Omori Y, Katoh K, Kondo M, Kanagawa M, Miyata K, Funabiki K, Koyasu T, Kajimura N, Miyoshi T, Sawai H, Kobayashi K, Tani A, Toda T, Usukura J, Tano Y, Fujikado T, *Furukawa T. Pikachurin, a dystroglycan ligand, is essential for photoreceptor ribbon synapse formation. Nat. Neurosci. 11: 923-931, 2008.
Kanagawa M, Nishimoto A, Chiyonobu T, Takeda S, Miyagoe-SuzukiY, Wang F, Fujikake N, Taniguchi M, Lu Z, Tachikawa M, Nagai Y, Tashiro F, Miyazaki J, Tajima Y, Takeda S, Endo T, Kobayashi K, Campbell KP, *Toda T. Residual laminin-binding activity and enhanced dystroglycan glycosylation by LARGE in novel model mice to dystroglycanopathy. Hum. Mol. Genet. 18: 621-631, 2009.
永井班
Fujikake N, *Nagai Y(equal contribution), Popiel HA, Okamoto Y, Yamaguchi M, Toda T. Heat shock transcription factor 1 (HSF1)-activating compounds suppress polyglutamine-induced neurodegeneration through induction of multiple molecular chaperones. J. Biol. Chem. 283: 26188-26197, 2008.
Bauer PO, Goswami A, Wong HK, Okuno M, Kurosawa M, Yamada M, Miyazaki H, Matsumoto G, Kino Y, Nagai Y, Nukina N. Harnessing chaperone-mediated autophagy for the selective degradation of mutant huntingtin protein. Nat. Biotechnol. 28: 256-263, 2010.
Nagai Y, Popiel HA. Conformational changes and aggregation of expanded polyglutamine proteins as therapeutic targets of the polyglutamine diseases: Exposed β-sheet hypothesis. Curr. Pharm. Des. 14: 3267-3279, 2008.
三木班 (平成18，19年度より継続)
Fujimoto W¶, Shiuchi T¶, Miki T,¶ (¶; contributed equally), Minokoshi Y, Takahashi Y, Takeuchi A, Kimura K, Saito M, Iwanaga T, *Seino S. Dmbx1 is essential in agouti-related protein action. Proc. Natl. Acad. Sci. U S A. 104: 15514-15519, 2007.
Shibasaki T, Takahashi H, Miki T, Sunaga Y, Matsumura K, Yamanaka M, Zhang C, Tamamoto A, Satoh T, Miyazaki J-I, *Seino, S. Essential role of Epac2/Rap1 signaling in regulation of insulin granule dynamics by cAMP. Proc. Natl. Acad. Sci. U S A. 104: 19333-193338, 2007.
Niimura M, Miki T, Shibasaki T, Fujimoto W, Iwanaga T, *Seino S. Critical role of the N-termial cyclic AMP-binding domain of Epac2A in its subcellular localization and function. J Cell Physiol. 219: 652-658, 2009.
Fujimoto W, Miki T, Ogura T, Zhang M, Seino Y, Satin L.S, Nakaya H, *Seino S. Niflumic acid-sensitive ion channels play an important role in the induction of glucose-stimulated insulin secretion by cyclic AMP in mice. Diabetologia. 52: 863-872, 2009.
Zhang CL, Katoh M, Shibasaki T, Minami K, Sunaga Y, Takahashi H, Yokoi N, Iwasaki M, Miki T, *Seino S. The cAMP sensor Epac2 is a direct target of antidiabetic sulfonylurea drugs. Science. 325: 607-610, 2009.
Yasuda T, Shibasaki T, Minami K, Takahashi H, Mizoguchi A, Uriu Y, Mori Y, Miyazaki J-I, Miki T, *Seino S. Rim2α determines docking and priming states in insulin granule exocytosis. Cell Metab. in press.
水島班 (平成18，19年度より継続)
Aburaya M, Tanaka K, Hoshino T, Tsutsumi S, Suzuki K, Makise M, Akagi R, *Mizushima T. Heme oxygenase-1 protects gastric mucosal cells against non-steroidal anti-inflammatory drugs. J. Biol. Chem. 281: 33422-33432, 2006.
Hoshino T, Nakaya T, Houman T, Sugimoto Y, Araki W, Narita M, Narumiya S, Suzuki T, *Mizushima T. Involvement of prostaglandin E2 in production of amyloid-β peptides both in vitro and in vivo. J. Biol. Chem. 282: 32676-32688, 2007.
Ushijima H, Hiasa M, Namba T, Hwang H-J, Hoshino T, Mima S, Tsuchiya T, Moriyama Y, Mizushima, T. Expression and function of TETRAN, a new type of membrane transporter. Biochem. Biophys. Res. Commun. 374: 325-330, 2008.
Namba T, Houman T, Nishimura T, Mima S, Hoshino T, *Mizushima T. Up-regulation of S100P expression by non-steroidal anti-inflammatory drugs and its role in their anti-tumorigenic effects. J. Biol. Chem. 284: 4158-4167, 2009.
Suemasu S, Tanaka K, Namba T, Ishihara T, Katsu T, Fujimoto M, Adachi H, Sobue G, Takeuchi K, Nakai A. *Mizushima, T. Role for HSP70 in protecting against indomethacin-induced gastric lesions. J. Biol. Chem. 284: 19705-19715, 2009.
Asano T, Tanaka K, Yamakawa N, Adachi H, Sobue G, Goto H, Takeuchi K. *Mizushima T. HSP70 confers protection against indomethacin-induced lesions of the small intestine. J. Pharmacol. Exp. Ther. 330: 458-467, 2009. (Selected for highlighted paper).
首藤班
Furuta T, *Shuto T (double first author), Shimasaki S, Ohira Y, Suico MA, Gruenert DC, *Kai H. DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription. BMC Mol Biol. 9: 39, 2008.
Shuto T, Ono T, Ohira Y, Shimasaki S, Mizunoe S, Watanabe K, Suico MA, Koga T, Sato T, Morino S, Sato K, *Kai H. Curcumin decreases toll-like receptor-2 gene expression and function in human monocytes and neutrophils. Biochem Biophys Res Commun. 2010. in press
馬場班
Wang Y, Deng X, Zhou Y, Hendron E, Mancarella S, Ritchie MF, Tang XD, Baba Y, Kurosaki T, Mori Y, Soboloff J, *Gill DL. STIM protein coupling in the activation of Orai channels. Proc. Natl. Acad. Sci. U S A. 106: 7391-7396, 2009.
Morita T, *Tanimura A, Baba Y, Kurosaki T, Tojyo Y. A Stim1-dependent, noncapacitative Ca2+-entry pathway is activated by B-cell-receptor stimulation and depletion of Ca2+. J. Cell Sci. 122: 1220-1228, 2009.
Baba Y, *Kurosaki T. Physiological function and molecular basis of STIM1-mediated calcium entry in immune cells. Immunological Review. 231: 174-188, 2009.
Kurosaki T, Baba Y. Ca2+ signaling and STIM1. Prog Biophys Mol Biol. in press
金井(正)班
Matsui T#, Kanai-Azuma M#, Hara K, Kawakami H, Kuhormaru M, Koopman P, *Kanai Y. Redundant roles of Sox17 and Sox18 in postnatal angiogenesis on mice. (#equal contribution) J Cell Sci . 119: 3513-3526, 2006.
Ishii M, Tachiwana T, Hoshino A, Tsunekawa N, Hiramatsu R, Matoba S, Kanai-Azuma M, Kawakami H, Kurohmaru M, *Kanai Y. Potency of testicular enviroment to support spermatogenesis in XX/Sry transgenic male mice. Development.134: 449-454, 2007.
■研究成果 - 新 聞 発 表
金井班
1. トランスポーター創薬が現実的に -分子同定から生体内の機能解明へ- 薬事日報 平成19年10月1日
1. トランスポーター「SGLT2 -糖尿病の新たな治療標的に- 薬事日報 平成20年10月24日
2. 肺がん進行度 PETで正確に診断 阪大など3～5年後実用化 日本経済新聞 平成21年9月21日
森班
1. 血管拡張の仕組み解明 狭心症や薄毛特効薬期待 京都新聞 平成18年9月25日
2. 血管拡張のカギにぎるたんぱく質 効果てきめん育毛剤期待 読売新聞 平成18年9月25日
3. ニンニク育毛に効く 血流量増やす成分判明 朝日新聞 平成18年9月25日
4. “ニンニクパワー”高血圧KO 産経新聞 平成18年9月25日
5. 育毛、ED新薬に光 スイッチ役たんぱく質特定 血管緩めて血流量増大 毎日新聞 平成18年9月25日
6. 神経細胞接点仕組み解明 情報運ぶ小胞に「綱と柱」 認知症治療一助に 京都新聞 平成19年5月14日
7. 神経伝達助けるタンパク質 京大グループ解明 認知症改善に期待 産経新聞 平成19年5月14日
8. 神経伝達物質放出の仕組み京大が解明 日本経済新聞 平成19年5月14日
9. 神経細胞伝達仕組みを解明 毎日新聞 平成19年5月14日
10. 「炎症」を悪化たんぱく確認 朝日新聞 平成20年6月11日
11. 炎症悪化させるタンパク質解明 毎日新聞 平成20年6月9日 (夕刊)
12. 炎症悪化の原因分子発見 日刊工業新聞 平成20年6月10日
13. 潰瘍性大腸炎など慢性炎症タンパク質の暴走原因か 京都新聞 平成20年6月9日 (夕刊)
14. 細胞のイオン取り込み阻害化合物を発見 京都新聞 平成21年3月17日 (夕刊)
古川班
1. 心電図QT延長問題と生薬 日経バイオテク 平成17年8月1日
2. 不整脈「QT延長症候群」性ホルモンが関与 予防や治療に興味深い研究 朝日新聞 平成19年2月6日
3. イオンチャネル研究 薬事日報 平成19年3月22日
竹島班
1. 記憶学習に安息期必要 京大チームタンパク質解明 京都新聞 平成18年6月27日
2. 脳神経細胞のたんぱく質記憶に重要な役割 毎日新聞 平成18年6月27日
3. 記憶のコツは休息 脳の神経細胞メカニズム解明 読売新聞 平成18年6月27日
4. 記憶に重要な働き たんぱく質を発見 日本経済新聞 平成18年6月27日
5. 記憶に必須タンパク質を解明 産経新聞 平成18年6月27日
6. 脳細胞つなぎ役 壊れると物忘れ 京大教授らマウスで実証 朝日新聞 平成18年6月27日
7. 細胞「小胞体」にイオン抜け道 心筋・免疫系新薬開発に道 毎日新聞 平成19年7月5日
8. 心臓拍動やホルモン分泌 仕組みの一つ解明 心臓病治療に一役も 日本経済新聞 平成19年7月5日
9. カルシウムイオン放出 支援のタンパク質発見 心疾患究明へ道 京都新聞 平成19年7月5日
10. 心臓疾患治療に光 未知のタンパク質発見 毎日新聞 平成19年7月5日
11. 細胞膜直すタンパク質解明 京都新聞 平成20年12月1日
12. 筋ジス原因物質発見 産経新聞 平成20年12月1日
13. 筋ジス原因遺伝子発見か 日本経済新聞 平成20年12月1日
14. 細胞膜の傷修復たんぱく質発見 読売新聞 平成20年12月1日
15. 細胞修復たんぱく質 毎日新聞 平成20年12月5日
日比野班
1. 耳の奥に“生体電池” 高知新聞 平成20年1月22日
2. 耳の電池が音増幅 中部経済新聞 平成20年1月23日
3. 耳器官内に音を増幅する“電池” 京都新聞 平成20年1月23日
楠見班
1. 細胞の情報伝達解明 BSE、エイズの感染過程研究に光 産經新聞 平成19年5月22日
2. 細胞外から内部にシグナル伝達 「ラフト」可視化に成功 日刊工業新聞 平成19年5月22日
3. 細胞内の情報「伝達役」発見 日本経済新聞 平成19年5月22日
4. たんぱく質や脂質の「イカダ」 細胞外から中へ信号を運ぶ 京大グループ発見 朝日新聞 平成19年5月28日
5. 細胞膜に「ラフト」形成 情報伝達の仕組み示す 京都新聞 平成19年5月31日
6. 細胞内情報伝える塊確認 たんぱく質の集合体移動 読売新聞 平成19年6月25日
根本班
1. 生きたマウスの脳撮影 毎日新聞 平成19年11月2日
2. 研究内容の紹介記事 中日新聞 平成20年11月2日
3. 生理研一般公開 毎日新聞 平成20年11月6日
4. 生理研一般公開及び蛍光タンパク質 読売新聞 平成20年12月１日
5. 生理研一般公開及びマウス大脳錐体細胞の３次元再構成像 朝日新聞 平成20年12月11日
6. 群青色蛍光タンパク質（シリウス） 日刊工業新聞 平成21年4月7日
7. 群青色蛍光タンパク質（シリウス） 日経産業新聞 平成21年4月7日
8. 群青色蛍光タンパク質（シリウス） 科学新聞 平成21年4月10日
宮本班
1. 食の証明 遺伝子レベル研究進む, 東京新聞 平成18年3月10日
2. 低リン食で寿命延長 フジ産経ビジネスi 平成18年5月17日
3. リン摂取控えて長生き 日経産業新聞 平成18年5月18日
4. 食の証明、リン過剰で老化 中日新聞 平成18年5月16日
5. リン過剰で老化 東京新聞 平成18年5月16日
6. 加工食品減らせば長寿？ 徳島大がショウジョウバエ実験 フジ産経ビジネスi 平成18年5月17日
寺崎班
1. 「ゴールド・メダル賞」授賞式 読売新聞 平成19年4月12日
2. 脳の「掃除役機能」解明 中枢支援・防御システムとしての新たな血液脳関門輸送機構の解明
2. 読売新聞 平成19年4月30日
3. 脳内のごみ排除、治療へ 読売新聞 平成19年10月19日
内田班
1. 塩分調節異常仕組み解明 遺伝性高血圧治療手がかりに 読売新聞 平成19年5月9日
2. 余分な食塩尿へ排せつ 血圧調整の仕組み解明 降圧薬開発も 毎日新聞 平成19年5月9日
3. 高血圧新薬に期待 塩分とりすぎ異常 仕組み解明へ一歩 朝日新聞 平成19年5月9日
4. 遺伝性高血圧症の分子病態解明 新たな降圧薬開発に可能性 科学新聞 平成19年5月11日
5. 尿崩症の仕組み解明 東医歯大 新薬開発に光 毎日新聞 平成20年8月12日
木下（専）班
1. 「悪玉」凝集で抑制 パーキンソン病タンパク質Sept4 役割を解明 京都新聞 平成19年2月16日
2. パーキンソン病発症抑制たんぱく質特定 読売新聞 平成19年2月16日
3. パーキンソン病悪化をストップ タンパク質の働き解明 中日新聞 平成19年2月16日
4. パーキンソン病治療に光明 因子のタンパク質発見 産経新聞 平成19年2月16日
5. パーキンソン病根本治療に道？ 悪玉抑えるたんぱく質解明 朝日新聞 平成19年2月16日
6. パーキンソン病発症関連たんぱく質実験で働き解明 日本経済新聞 平成19年2月16日
7. 神経細胞つくるタンパク質 セプチンの機能解析 中日新聞 平成21年1月23日
8. 細胞形状の変形過程解明 たんぱく質セプチン関与 顕微鏡で可視化 日刊工業新聞 平成21年1月23日
高森班
1. 脳興奮性神経伝達で脳内塩素イオンが重要な役割 科学新聞 平成21年2月6日
月田班
1. 腸のたんぱく質細胞分裂を促進 阪大教授ら英誌に発表 朝日新聞 2008年7月21日
森山班
1. 痛みを輸送するたんぱく質 発見 読売新聞 平成20年5月12日
2. 記憶にかかわるアスパラギン酸 輸送タンパク質発見 難病の新薬開発に期待 山陽新聞 平成20年8月12日
3. 岡山大学がトランスポーター新発見 RSKニュース岡山・香川 山陽放送 平成20年8月12日
4. 脳内で記憶や学習に関係 アスパラギン酸運ぶ物質岡山大グループが発見 読売新聞 平成20年8月18日
5. 「アスパラギン酸」記憶に関与？ 岡山大グループが解明 朝日新聞 平成20年8月18日
6. 記憶の仕組みにアスパラガスのアミノ酸 岡山大が解明 asahi..com 平成20年8月20日
7. 脳神経細胞の研究に期待 記憶障害の病気と関係も 神経伝達の新たな物質か 聖教新聞 平成20年9月19日
8. プリン性化学伝達の分子基盤と創薬展開 オーガナイザー 森山芳則、加藤総夫 薬事日報 平成21年3月18日
酒井班
1. 細胞形状の変形過程解明 たんぱく質セプチン関与 顕微鏡で可視化 日刊工業新聞 平成21年1月23日
久保班
1. カフェインで鎮痛 毎日新聞 平成20年10月28日」
2. カフェイン効果 対照的 マウスには「痛み」、人間には鎮痛薬 中日新聞 平成20年10月29日
3. カフェインに鎮痛効果 日本経済新聞 平成20年10月29日」
4. カフェインを鎮痛剤に 日刊工業新聞 平成20年10月29日」
梅田班
1. 遺伝子操作で「暑がり」ハエ 京大チーム、実験に成功 日本経済新聞 平成21年3月27日
2. 暑がり遺伝子」京大チーム発見 ハエで実験 体温調節を解明へ 京都新聞 平成21年3月27日
3. 遺伝子壊れるとハエ「暑がり」に 京大教授ら幼虫で実験 朝日新聞 平成21年3月28日 (夕刊)
4. 遺伝子操作 実験でハエ暑がりに 毎日新聞 平成21年3月27日